Left Ventricle Phenotyping Utilizing Tissue Doppler Imaging in Premature Infants with Varying Severity of Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is characterized by alveolar-capillary simplification and associated with pulmonary hypertension (PH) in preterm infants. The contribution of left ventricle (LV) disease towards this severe BPD-PH phenotype not well established. We aimed to describe the longitudinal trajectory LV function as measured tissue Doppler imaging (TDI) its association BPD-PH. retrospectively assessed prospectively acquired clinical echocardiographic data from 77 infants born between 2011 2013. measuring systolic diastolic myocardial velocities (s’, e’, a’), isovolumetric relaxation time (IVRT), performance index TDI at three periods 32 36 weeks, postmenstrual age through one year age. also post motion (PSM), a marker dysfunction that results asynchronous movement ventricular walls, previously described Patients were stratified into groups according BPD severity presence PH compared over time. Conventional measures similar groups, but septal PSM was significantly prolonged first patients provides novel objective way assess hemodynamic impact lung vascular on PH.